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SIRT5 IS A DRUGGABLE METABOLIC VULNERABILITY IN ACUTE MYELOID LEUKEMIA.
Yan D, Franzini A, Pomicter AD, Halverson BJ, Antelope O, Mason CC, Ahmann JM, Senina AV, Vellore NA, Jones CL, Zabriskie MS, Than H, Xiao MJ, van Scoyk A, Patel AB, Clair PM, Heaton WL, Owen SC, Andersen JL, Egbert CM, Reisz JA, D'Alessandro A, Cox JE, Gantz KC, Redwine HM, Iyer SM, Khorashad JS, Rajabi N, Olsen CA, O'Hare T, Deininger MW. Yan D, et al. Among authors: rajabi n. Blood Cancer Discov. 2021 May;2(3):266-287. doi: 10.1158/2643-3230.BCD-20-0168. Epub 2019 Dec 2. Blood Cancer Discov. 2021. PMID: 34027418 Free PMC article.
Mitochondria-targeted inhibitors of the human SIRT3 lysine deacetylase.
Troelsen KS, Bæk M, Nielsen AL, Madsen AS, Rajabi N, Olsen CA. Troelsen KS, et al. Among authors: rajabi n. RSC Chem Biol. 2021 Feb 1;2(2):627-635. doi: 10.1039/d0cb00216j. eCollection 2021 Apr 1. RSC Chem Biol. 2021. PMID: 34458804 Free PMC article.
Aryl Fluorosulfate Based Inhibitors That Covalently Target the SIRT5 Lysine Deacylase.
Bolding JE, Martín-Gago P, Rajabi N, Gamon LF, Hansen TN, Bartling CRO, Strømgaard K, Davies MJ, Olsen CA. Bolding JE, et al. Among authors: rajabi n. Angew Chem Int Ed Engl. 2022 Nov 21;61(47):e202204565. doi: 10.1002/anie.202204565. Epub 2022 Oct 21. Angew Chem Int Ed Engl. 2022. PMID: 36130196 Free PMC article.
Mechanism-based inhibitors of SIRT2: structure-activity relationship, X-ray structures, target engagement, regulation of α-tubulin acetylation and inhibition of breast cancer cell migration.
Nielsen AL, Rajabi N, Kudo N, Lundø K, Moreno-Yruela C, Bæk M, Fontenas M, Lucidi A, Madsen AS, Yoshida M, Olsen CA. Nielsen AL, et al. Among authors: rajabi n. RSC Chem Biol. 2021 Jan 14;2(2):612-626. doi: 10.1039/d0cb00036a. eCollection 2021 Apr 1. RSC Chem Biol. 2021. PMID: 34458803 Free PMC article.